Association Between Cardiovascular-Kidney-Metabolic Syndrome and Myocardial Injury After Noncardiac Surgery: A Retrospective Cohort Study.

JACC Asia · 2026 · PMC13244111 · PMID 41830942

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did not reach statistical significanceno p-value reported

Furthermore, the sensitivity analysis of underweight patients within stage 0 showed a trend toward increased MINS risk (OR: 1.49; P = 0.10) that did not reach statistical significance, potentially due to limited sample size (n = 341).

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showed a trendno p-value reported

When adjusting for surgery-related variables (model 3), stage 1 showed a trend toward protection but without statistical significance (OR: 0.79; 95% CI: 0.63-1.01; P = 0.057), stage 2 remained nonsignificant (OR: 1.13; 95% CI: 0.94-1.35; P = 0.210), and stages 3 (OR: 2.20; 95% CI: 1.81-2.66; P < 0.001) and 4 (OR: 2.85; 95% CI: 2.32-3.51; P < 0.001) demonstrated strong associations with the risk for MINS.

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