Barely Significant
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Hyperbaric oxygen therapy improves clinical symptoms and functional capacity and modulates thalamic connectivity in ME/CFS: a prospective cohort study.

J Transl Med · 2026 · PMC13244963 · PMID 42249466

2
hedged sentences
0.0960
closest p · 1.9× alpha
0.1100
boldest claim

The sentences

showed a trendp = 0.096so close (0.05 < p ≤ 0.1)
In univariate analyses, lower baseline CFQ physical fatigue scores showed a trend toward predicting response (odds ratio (OR) = 0.79, 95% CI: 0.58–1.02; p = 0.096), whereas baseline SF-36 general health (OR = 1.02, 95% CI: 0.96–1.08; p = 0.50) and baseline SDMT performance (OR = 1.04, 95% CI: 0.51–2.18; p = 0.92) were not associated with response.

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did not reach statistical significancep = 0.11not close (p > 0.1)
In the multivariable model including all three predictors, lower baseline CFQ physical fatigue remained the strongest predictor, although the association did not reach statistical significance (OR = 0.76, 95% CI: 0.50–1.03; p = 0.11).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.