Barely Significant
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Natural Flavonoids Genistein and Baicalein as Well-Tolerated Radiosensitizers to Enhance the Efficacy of <sup>177</sup>Lu-PSMA617 in Prostate Cancer: In Vitro and In Vivo Studies.

Research (Wash D C) · 2026 · PMC13250281 · PMID 42281770

2
hedged sentences
0.0001
closest p · 0.0× alpha
0.0001
boldest claim

The sentences

highly significantP < 0.0001actually significant
Survival benefit and safety profile Kaplan–Meier survival analysis revealed a highly significant intergroup difference (log-rank test, P < 0.0001).

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did not reach statistical significanceP > 0.05actually significant
a strong trendno p-value reported
At this time point, the 177 Lu-PSMA617 + genistein group exhibited a 78.1% reduction in tumor volume compared to 177 Lu-PSMA617 monotherapy, while the 177 Lu-PSMA617 + baicalein group showed a 50.2% reduction, demonstrating a strong trend of enhanced efficacy, although these differences did not reach statistical significance ( P > 0.05) (Fig. 4 B).

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