Retatrutide Shows Multiple Metabolic Benefits in Diet-Induced Obese MASH Mouse and Hamster Models.

Compared with B6 DIO MASH mice treated with vehicle, retatrutide tended to lower plasma free fatty acid levels, but this did not reach statistical significance ( p = 0.0565 vs. vehicle).

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Retatrutide Strongly Reduces Body Weight With Significant Reduction in Fat and Lean Mass and Food Intake but Unchanged Energy Expenditure in B6 DIO MASH Mice While vehicle‐treated B6 DIO MASH mice showed a trend toward higher body weight, those treated with retatrutide showed a rapid and substantial weight loss that sustained until the end of the treatment period (Figure 1A ).

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