Lateralized glymphatic system impairment in acute ischemic stroke: a DTI-ALPS study of upper limb motor function.

First, the sample size was relatively small, and no stratification analysis was performed for confounding factors such as infarct volume and etiological classification; therefore, the lack of a significant trend observed in the ALPS index for the right hemisphere may reflect insufficient statistical power rather than a true pattern of the effect.

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Some clinically meaningful trends did not reach statistical significance, likely because of the small sample size and a single early time point.

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