Loss of FAM60A disrupts Sin3/HDAC control of the Hippo signaling and promotes oncogenic YAP1 activation.

Although these associations did not reach statistical significance, the directionality of the hazard ratios is consistent with our proposed mechanistic model and provides preliminary clinical context for the FAM60A–WWC3–YAP1 regulatory axis.

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Kaplan–Meier analysis showed that higher expression of FAM60A (hazard ratio [HR] = 0.88, p = 0.36) and WWC3 (HR = 0.83, p = 0.27) was associated with a trend toward improved overall survival, whereas elevated YAP1 expression (HR = 1.21, p = 0.34) showed a trend toward poorer outcomes (Fig. 6I-K ).

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