Effects of fasudil on disease spreading in ALS - A MUNIX-based post-hoc analysis of the ROCK-ALS trial.

For the 10% threshold, a similar trend was observed: fasudil treatment groups exhibited fewer newly affected muscles on day 90, but the differences did not reach statistical significance.

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The MUNIX-10 score at baseline did not correlate with serum biomarkers (NfL or GFAP) or the ALSFRS-R score at baseline, however, it showed a trend toward a positive correlation with sVC (rho = 0.28; p raw = 0.01, p adj = 0.11) Change in MUNIX over time Of all 78 patients with complete MUNIX measurements (including all 10 muscles), 67 participants (86%) had at least one complete follow-up assessment, either after 3 months (17 participants) or after 6 months (50 participants).

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