Vitamin D<sub>3</sub> and Dimethyl Fumarate Partially Restore Neurotrophic Signaling Without Altering Mitochondrial Integrity in the STZ-Induced Model of Sporadic AD.

Int J Mol Sci · 2026 · PMC13256348 · PMID 42278468

Europe PMC DOI

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0.0700

closest p · 1.4× alpha

0.0700

boldest claim

The sentences

showed a trendp = 0.07so close (0.05 < p ≤ 0.1)

STZ administration showed a trend toward reduced mature BDNF content compared with the SHAM group ( p = 0.07), whereas combined VitD 3 and DMF treatment significantly increased mature BDNF content compared with the STZ group.

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did not reach statistical significanceno p-value reported

IGF-1 protein content showed a lower mean value in the STZ group compared with the SHAM group, whereas higher mean values were observed in the treatment groups; however, these differences did not reach statistical significance ( Figure 2 A).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.

Vitamin D&lt;sub&gt;3&lt;/sub&gt; and Dimethyl Fumarate Partially Restore Neurotrophic Signaling Without Altering Mitochondrial Integrity in the STZ-Induced Model of Sporadic AD.

The sentences

Vitamin D<sub>3</sub> and Dimethyl Fumarate Partially Restore Neurotrophic Signaling Without Altering Mitochondrial Integrity in the STZ-Induced Model of Sporadic AD.