Pharmacological Inhibition of SP1 Reverses Cancer Stemness and Enhances Sorafenib Efficacy in Hepatocellular Carcinoma.

Cells · 2026 · PMC13256930 · PMID 42274554

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a decreasing trendno p-value reported

did not reach statistical significanceno p-value reported

Consistent with these transcriptional changes, Western blot analysis confirmed a significant reduction in OCT4 protein levels, while NANOG protein expression showed a decreasing trend that did not reach statistical significance ( Figure 8 E).

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showed a trendno p-value reported

In contrast, HepG2 cells displayed a milder transcriptional response: OCT4 , SOX2 , NANOG , and KLF4 showed a trend toward upregulation (not significant), while PROM1 /CD133 and CD24 were consistently reduced.

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