Intravenous thrombolysis for acute ischemic stroke in the extended time window of 4.5-24 h: a systematic review and network meta-analysis of randomized controlled trials.

For the primary outcome of 90-day mRS 0–2, compared with SoC, rt-PA significantly increased the proportion of functionally independent patients (RR = 1.21, 95% CI 1.06–1.38, low certainty), JX10 (RR = 1.50, 95% CI 0.87–2.58, very low certainty) and TNK (RR = 1.07, 95% CI 0.93–1.23, low certainty) showed a trend toward improvement but did not reach statistical significance.

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