Tacrolimus Concentration/Dose Ratio in Hematopoietic Cell Transplantation Recipients: An Exploratory Study of Metabolizer Phenotyping and Clinical Outcomes.

In contrast, fast metabolizers showed a trend toward increased incidence of acute graft‐versus‐host disease (aGVHD) (HR 1.91; 95% CI 0.93–3.92) and an almost universal need for dose escalation (96.8%).

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In this context, our findings provide clinically relevant insights by demonstrating that a higher tacrolimus C/D ratio is significantly associated with the occurrence of moderate‐to‐severe acute AKI, by suggesting a nonsignificant trend toward higher aGVHD incidence among fast metabolizers, and by showing distinct patterns of dose adjustment between metabolizer groups.

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The cumulative incidence of acute GVHD within 100 days after transplantation was higher in fast metabolizers compared with slow metabolizers, although the difference did not reach statistical significance by the log‐rank test.

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