Chrysin Attenuates Dry Eye Progression by Suppressing NOX2-Dependent Ferroptosis and STING/NLRP3-Mediated Inflammatory Responses.

Chrysin at 2 μM and 6 μM showed a trend toward improving cell viability, although the changes did not reach statistical significance.

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Consistent with the aforementioned results, the BAC group exhibited increased expression of Nox2, Lcn2, Hmox1, Timp1, Il-6, and Nos2, although the elevation of Nos2 did not reach statistical significance ( Fig. 1 D).

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On day 2, the cotton thread wetting length in the BAC+DMSO sham-treatment group showed a decreasing trend compared with both the PBS+DMSO control group and the BAC+chrysin treatment group, although the differences were not statistically significant.

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