<i>DDERMMAL</i>, a melanocytic long non-coding RNA, confers DNA damage tolerance to melanoma cells.

However, within DT-exposed tumors, a clear trend toward higher DDERMMAL levels was observed at T relapse (drug-resistant cells) compared to T 4 (drug-tolerant cells after 4 days exposure to treatment) ( Figure 2 H-I), although this difference did not reach statistical significance ( p = 0.08), suggesting a re-establishment of melanocytic programs that may enable proliferative expansion at relapse.

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