Outcomes of patients with or without DNA repair pathway alterations: the MD Anderson IMPACT2 study.

NPJ Precis Oncol · 2026 · PMC13265806 · PMID 41963611

Europe PMC DOI

hedged sentences

0.1700

closest p · 3.4× alpha

0.1700

boldest claim

The sentences

showed a trendp = 0.17not close (p > 0.1)

A meta-analysis of eight trials in mCRPC patients treated with PD-L1 inhibitors with or without CTLA-4 blockade demonstrated that DDR-positive status correlated with improved PFS (OR 0.70; Z = 2.48, p = 0.01) and showed a trend toward longer OS (OR 0.71, Z = 1.38; p = 0.17) 58 .

also in 53,322 other papers

highly significantno p-value reported

Highly significant co-occurrences involved genes mapped to the same chromosomes, including CCND1 with FGF19 and FGF3 with FGF19 (chromosome 11); CDKN2A with MTAP , CDKN2A with CDKN2B , and MTAP with CDKN2B (chromosome 9); and YEATS4 with FRS2 and CDK4 with MDM2 (chromosome 12) ( all p < 0.001).

also in 132,142 other papers

did not reach statistical significanceno p-value reported

The p -values for other genes did not reach statistical significance (Table S3 ).

also in 111,027 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.