Pink lotus flower (<i>Nelumbo nucifera</i>) oil extract alleviates imiquimod-induced psoriasis-like dermatitis.

By contrast, the levels of IL-10 in both dorsal skin and serum showed an increasing trend in the IMQ + PLO-200 group compared with in the IMQ + NS group; however, this difference was not statistically significant ( Fig. 4E and F ).

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Furthermore, K16 expression was significantly reduced in the IMQ + MTX group compared with in the IMQ + NS group and IMQ + PLO treated groups; however, although a decreasing trend was observed in the IMQ + PLO groups relative to the IMQ + NS group, the differences did not reach statistical significance ( Fig. 3D ).

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Furthermore, the PLO-treated groups (100 and 200 mg/kg body weight) showed a trend toward improved body weight compared with the IMQ + NS group, but these differences were not statistically significant.

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Related skin manifestations tended to be ameliorated in the IMQ + PLO-100 and IMQ + PLO-200 groups, as reflected by lower PASI scores, which were consistent with the effects observed in the MTX-treated group; however, these reductions did not reach statistical significance.

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