Sleep deprivation following hippocampus-dependent learning downscales synaptic inputs to lateral and medial entorhinal cortex interneurons.

Moreover, the proportion of detected spines in MEC with filopodial morphology was negatively correlated with SD interventions required ( Figure 3 , bottom; Pearson’s r = −0.94, p < .05), while the proportion with stubby morphology showed a trend for positive correlation with SD interventions (Pearson’s r = 0.88, p = .051).

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Mushroom spines showed a strong trend for increased representation after SD and thin spines showed a corresponding trend for decreased representation (Sleep mushroom spines = 18.8% + 1.2%, SD mushroom spines = 22.8% + 2.0%, nested t -test, p = .053; Sleep thin spines = 31.4% + 4.3%, SD thin spines = 26.0% + 3.2%, nested t -test, p = .098).

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