On the Origin of the Brain Semi-Heavy Water Deuterium MR Signal Following Administration of Deuterated Metabolic Substrate: A Cautionary Tale.

Additionally, although not reaching statistical significance, comparison of brain Glx concentrations between Glut1+/+ and littermate‐control Glut1+/− mice administered Fruc showed a strong trend ( p = 0.056) toward an expected decrease in Glx for the Glut1+/− cohort, which has the lowest sugar concentration, providing further evidence identifying the brain sugar signal following Fruc administration as Glc*.

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Nevertheless, consistent with the Glc* level in the Glut1+/− cohort being ∼50% that in the Glut+/+ cohort, the brain Glx signal in the Glut1+/− cohort showed a trend ( p = 0.056, unpaired t ‐test; p = 0.17 two‐way ANOVA with Tukey's multiple comparisons test) toward an expected decrease compared to the Glut1+/+ cohort, again supporting identification of the sugar signal as Glc* (i.e., Glc* → pyruvate → acetyl‐CoA → TCA cycle → Glx). 4.

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