Expression of GPR34 in microglia remains stable in human Alzheimer's disease.

For Braak stages, point estimates ranged from r = ‒0.52 (DFC × MKI67) to r = +0.19 (STG × TPT1), with the strongest nominally significant correlation observed in AnG across all microglia ( r = ‒0.38, p = 0.011).

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Although median GPR34 signal counts tended to increase from low to high Aβ burden in both EC (12.50 [10.76], 19.78 [8.02], 31.12 [17.63]) and TC (14.52 [7.95], 16.60 [10.11], 34.78 [13.89]), this trend was inconsistent across individual cases and did not reach statistical significance (Fig. 4 e).

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