approached significanceP = 6.9 × 10 −6
In AFR analyses, PLA2G5 was significantly associated with CFR in men (uncorrected P = 2.2 × 10 −8 ), and CAPN2 approached significance in women (uncorrected P = 6.9 × 10 −6 ).
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Genome-wide association study of coronary flow reserve assessed by cardiac perfusion PET suggests a role for NF-κB pathway.
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approaching significanceP < 0.05
Across all analyses, one transcriptome-wide significant association with the CFR phenotype emerged from the AFR cohort analyses as well as one association approaching significance after Benjamini–Hochberg (false discovery rate (FDR)) correction ( P < 0.05).