Development and Clinical Application of a Real-World Population Pharmacokinetic Model of Rivaroxaban in Asian Patients with Atrial Fibrillation.

Conversely, patients with high estimated Ct values showed a trend toward an increased risk of major bleeding, with an incidence of 2.88 per 100 person-years compared with 1.15 in the within-range group (log-rank P = 0.64; HR and 95% CI 2.49 [0.31, 20.18], P = 0.39).

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This evaluation was conducted to determine whether any of these parameters exhibited a significant trend that would warrant their incorporation into the final PPK model.

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