Three-week actigraphy to assess sleep behaviour and circadian rest-activity patterns in suspected and confirmed Cushing's syndrome: an exploratory prospective cohort study.

Pituitary · 2026 · PMC13272607 · PMID 42301348

Europe PMC DOI

hedged sentences

0.0810

closest p · 1.6× alpha

0.0950

boldest claim

The sentences

did not reach statistical significancep = 0.081so close (0.05 < p ≤ 0.1)

those with persistent adrenal insufficiency, which did not reach statistical significance (0.9 ± 0.2 vs. 0.7 ± 0.2, p = 0.081; Table 4 ), we did not observe significant differences in interdaily stability and intradaily variability.

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showed a trendp = 0.095so close (0.05 < p ≤ 0.1)

Patients with persistent adrenal insufficiency showed a trend towards earlier onset of the least active L5 period ( p = 0.095) and an earlier acrophase, though not statistically significant ( p = 0.079; Table 4 ).

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