Targeting the cGAS-STING pathway mitigates Huntington disease pathogenesis in a knock-in mouse model.

Proc Natl Acad Sci U S A · 2026 · PMC13273248 · PMID 42258722

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did not reach statistical significanceno p-value reported

Although there was a trend toward increased levels across the broader HEPE and HETE families ( Dataset S6 ), these changes did not reach statistical significance ( Fig. 7 D and E ).

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showed a trendno p-value reported

In contrast, ω-3 fat, docosahexaenoic acid–derived HDHAs showed a trend of increase in the HD cortex but were not altered by cGAS deletion ( Fig. 7 F ).

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