ENT1 inhibitor J4 restores cognitive function and white-matter integrity in a mouse model of tuberous sclerosis complex.

J Biomed Sci · 2026 · PMC13274077 · PMID 42310739

Europe PMC DOI

hedged sentences

0.0507

closest p · 1.0× alpha

0.0792

boldest claim

The sentences

showed a trendp = 0.0507so close (0.05 < p ≤ 0.1)

In contrast, myelin density showed a trend toward reduction in Tsc2 + /– Veh (F(2, 6) = 5.107, p = 0.0507), with a significant difference between WT Veh and Tsc2 + /– Veh ( p = 0.0193).

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did not reach statistical significancep = 0.0792so close (0.05 < p ≤ 0.1)

J4 treatment showed a trend toward increased CNPase immunoreactivity compared with Tsc2 + /– Veh, although this difference did not reach statistical significance (p = 0.0792), and no significant changes were observed between WT Veh and Tsc2 + /– J4 ( p = 0.5926).

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