<i>Polygonatum sibiricum</i> combined with <i>Poria cocos</i> prevents spleen deficiency constipation via the gut microbiota-mediated brain-gut axis.

Similarly, for serum MTL ( Figure 3C ), the NMs level was profoundly lower than that of the NC ( p < 0.001), and the HF demonstrated a highly significant increase compared to the NM ( p < 0.001).

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As shown in Figure 3A , the serum 5-HT concentration in the model group did not differ significantly from that in the normal group, but showed a decreasing trend.

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Furthermore, as shown in Figure 1D , the fecal moisture content of the NM was significantly lower ( p < 0.05), and the fecal moisture content of the HF of mice showed an increasing trend, but this difference did not reach statistical significance. 3.2 Effects of the combination of Polygonatum sibiricum and Poria cocos on colon pathology in mice with spleen deficiency constipation A normal intestine is composed of the mucosal, submucosal, muscular, and serosal layers.

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Quantitative analysis showed that, compared with the NM, the HF crypt length showed a trend of recovery, but this difference did not reach statistical significance ( Figure 2B ).

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