A prospective multimethod investigation of cancer-related pain integrating clinical data and machine learning: results from the RUGGI Study.

J Anesth Analg Crit Care · 2026 · PMC13277234 · PMID 42057124

Europe PMC DOI

hedged sentences

0.0540

closest p · 1.1× alpha

0.0780

boldest claim

The sentences

showed a trendp = 0.054so close (0.05 < p ≤ 0.1)

Metastatic disease showed a trend toward higher pain (median: 5.5 vs 4, U = 965.5, p = 0.054, r = 0.21), approaching statistical significance with a small-to-medium effect size.

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a trend toward significancep = 0.078so close (0.05 < p ≤ 0.1)

Heart failure showed a trend toward significance (β = −1.99, p = 0.078), while antidepressant use (β = −1.17, p = 0.103) and depression (β = 1.98, p = 0.115) approached but did not reach the significance threshold.

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approached significanceno p-value reported

However, the comparison between the category “Others” and limb pain approached significance with uncorrected p equals 0.0089.

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