Dynamic Changes in Midbrain-Striatal Association and Their Relationship With Levodopa-Induced Dyskinesia in Parkinson's Disease.

Parkinsons Dis · 2026 · PMC13277766 · PMID 42327575

Europe PMC DOI

hedged sentences

0.0770

closest p · 1.5× alpha

0.0900

boldest claim

The sentences

did not reach statistical significancep = 0.077so close (0.05 < p ≤ 0.1)

For 4‐year midbrain SBR, the association with LID did not reach statistical significance after adjustment ( β = −0.06, p = 0.077; Supporting Table S3 ).

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a trend toward significancep = 0.09so close (0.05 < p ≤ 0.1)

At the 4‐year follow‐up, the regression slope for this association was notably higher in the LID group compared to the non‐LID group, with the interaction term showing a trend toward significance ( p = 0.09, q = 0.15).

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showed a trendp = 0.09so close (0.05 < p ≤ 0.1)

In multivariable regression models adjusting for baseline clinical differences, the interaction between midbrain SBR and LID status for the 4‐year putamen SBR showed a trend‐level association ( p = 0.09, q = 0.15).

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