Progestogen supplementation to prevent miscarriage: Evidence and controversies.

Int J Gynaecol Obstet · 2026 · PMC13278652 · PMID 41498246

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showed a trendno p-value reported

Notably, the trial showed a trend for greater benefit with an increasing number of previous miscarriages, generating the hypothesis that a subgroup effect existed with a biological gradient related to the increasing number of previous miscarriages. 20 2.2.

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did not reach statistical significanceno p-value reported

The authors found a 3% greater live birth rate with vaginal progesterone, but the results did not reach statistical significance.

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