Age-related anabolic resistance and post-absorptive muscle protein synthesis: integrative evidence from a systematic review and meta-analysis.

Front Physiol · 2026 · PMC13278896 · PMID 42326998

Europe PMC DOI

hedged sentences

0.0260

closest p · 0.5× alpha

0.0650

boldest claim

The sentences

borderline significantp = 0.026actually significant

Sensitivity analyses restricted to early-phase MPS measurements resulted in a pooled SMD of−0.354 (95% CI: −0.632 to −0.076; p = 0.013), whereas inclusion of late (± middle) phase measurements attenuated the pooled effect (SMD range: −0.265 to −0.227) but remained statistically significant or borderline significant (p = 0.026–0.050).

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borderline non-significantp = 0.065so close (0.05 < p ≤ 0.1)

Excluding one study rendered the overall effect borderline non-significant ( p = 0.065), indicating moderate but not critical sensitivity.

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did not reach statistical significanceno p-value reported

Limited power or sex-specific variability in postprandial muscle protein synthesis may explain why these differences did not reach statistical significance.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.