Enhanced Human Antigen-Specific B Cell Responses Using In Vitro 3D Tonsil Cultures Containing Stromal Cells.

Adv Healthc Mater · 2026 · PMC13279853 · PMID 41988691

Europe PMC DOI

hedged sentences

0.0900

closest p · 1.8× alpha

0.0900

boldest claim

The sentences

showed a trendp = 0.09so close (0.05 < p ≤ 0.1)

In addition, GC and ASC populations were more prominent in 3D FRC‐supported cultures than in 2D cultures, particularly after stimulation with the influenza vaccine, which showed a trend toward higher GC/ASC frequencies compared to unstimulated conditions (4‐fold increase; p = 0.09; Figure 4B ).

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did not reach statistical significanceno p-value reported

We observed improved B‐cell survival in the U‐bottom FRC‐supported condition, also supported by previous optimization studies [ 17 ], although differences did not reach statistical significance.

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