Comparison of perioperative chemotherapy and neoadjuvant chemoradiotherapy (CRT) in locally advanced resectable distal esophageal/esophagogastric junction (EGJ) adenocarcinomas.

BMC Cancer · 2026 · PMC13281352 · PMID 42151898

Europe PMC DOI

hedged sentences

0.0540

closest p · 1.1× alpha

0.1000

boldest claim

The sentences

did not reach statistical significancep = 0.054so close (0.05 < p ≤ 0.1)

Although the proportion of male patients was higher in the perioperative group, the difference in sex distribution did not reach statistical significance ( p = 0.054).

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showed a trendp = 0.078so close (0.05 < p ≤ 0.1)

In subgroup analyses, neoadjuvant CRT showed a trend toward improved OS in EGJ stage II ( p = 0.078) and a significant RFS benefit in distal stage II ( p = 0.014), whereas perioperative ChT demonstrated a significant OS advantage in EGJ stage III ( p = 0.020).

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borderline significantp < 0.10so close (0.05 < p ≤ 0.1)

The log-rank p-value was 0.078, suggesting a borderline significant difference ( p < 0.10).

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a numerical trendno p-value reported

Although the log-rank p-value was 0.164 and therefore not statistically significant, a numerical trend favoring neoadjuvant CRT was observed.

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borderline significanceno p-value reported

Indeed, the presence of broad confidence intervals and borderline significance levels in some categories suggests limited statistical power.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.