Association Between Hemostatic Profiles and Hypertensive Disorders of Pregnancy: A Multi-Omics Mendelian Randomization Study.

However, these associations did not reach statistical significance after Bonferroni correction and Bayesian colocalization analysis indicated low posterior probabilities for a shared causal variant.

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Results Our two-sample MR analysis identified nominally significant associations between genetically predicted higher vWF (OR 1.27, 95% CI 1.06–1.51), FVIII (OR 2.21, 95% CI 1.05–4.66), and lower Protein C (OR: 0.91, 95% CI: 0.83–0.99) with a higher risk of preeclampsia.

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