Role of WDR66 in Stemness, Therapy Resistance and Tumor microenvironment modulation in Head and Neck Cancer.

Int J Biol Sci · 2026 · PMC13282750 · PMID 42328431

Europe PMC DOI

hedged sentences

0.1313

closest p · 2.6× alpha

0.1313

boldest claim

The sentences

showed a trendp=0.1313not close (p > 0.1)

We found that overexpression of WDR66 showed a trend toward an increase of CD10+ cells in RPMI 2650 (p=0.1313), while a decrease in CD10+ (and CD184+) cells was observed in Detroit 562 ( Fig. 3 C ).

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did not reach statistical significanceno p-value reported

Indeed, WDR66 increased the number of iPSC colonies obtained in a fibroblast reprogramming assay, although the effect did not reach statistical significance.

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an increasing trendno p-value reported

Therefore, these results suggest that, although the differences were not statistically significant, WDR66 could play a role in cellular reprogramming because we observed an increasing trend in the number of induced pluripotent colonies when we overexpressed WDR66.

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