Efficacy of intraoperative topical Sapylin (OK-432) for preventing lymph leakage following inguinal lymph node dissection in melanoma: a retrospective cohort study.

No significant association was found between the number of positive lymph nodes and lymphatic leakage (overall P = 0.20), although patients with ≥ 3 positive lymph nodes showed a trend toward lower risk (OR = 0.22, 95% CI: 0.04–1.18, P = 0.08).

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In the low-burden group (1 positive lymph node), Sapylin significantly reduced the risk of lymphatic leakage ( P = 0.05), whereas in the intermediate- and high-burden groups (≥ 2 positive lymph nodes), the effect did not reach statistical significance but showed a direction consistent with the overall analysis (OR = 0.48).

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