Cost utility and cost-effectiveness of the APPLE-Tree programme: Active Prevention in People at risk of dementia through Lifestyle, bEhaviour change and Technology to build REsiliEnce: economic evaluation embedded within a randomised controlled trial.

Age Ageing · 2026 · PMC13284706 · PMID 42328805

Europe PMC DOI

hedged sentences

0.0550

closest p · 1.1× alpha

0.0550

boldest claim

The sentences

approached significanceP = .055so close (0.05 < p ≤ 0.1)

Although this analysis was not specified in the original HEAP unless a statistically significant effect on NTB was observed, it was conducted as an exploratory secondary analysis because the primary analysis approached significance ( P = .055).

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did not reach statistical significanceP = .055so close (0.05 < p ≤ 0.1)

These findings broadly align with those from other randomised controlled trials (RCTs), in which multimodal lifestyle interventions have been associated with small, positive changes on cognitive outcomes, relative to control conditions [ 12–14 ], although the APPLE-Tree trial did not reach statistical significance at 24 months ( P = .055).

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