Multi‑scale immune and spatial profiling of sclerosing adenosis and surrounding breast tissue identifies an immune‑cold field phenotype associated with breast cancer risk.

In patient-clustered models, the CD68+–Ki67+ contrast remained significant (cluster-robust P = 0.0228, BH-FDR q = 0.035), whereas the CD8+–Ki67+ contrast was nominally significant but slightly above the BH-FDR threshold ( P = 0.0432, q = 0.052; Supplemental Table S5 ).

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Epithelial panCK+ densities also tended to decrease from lobules to lesions in most patients, with a larger mean decrease in cases than in controls, although this between-group difference did not reach statistical significance.

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