IL-8 blockade enhances anti-PD-1 therapeutic activity in renal cell carcinoma in a next-generation patient-derived xenograft model.

High M-MDSC gene signature is associated with poor OS in the CheckMate 025 trial In our institutional cohort, we performed Kaplan-Meier survival analyses stratified by high versus low peripheral M-MDSC levels; however, due to the limited sample size ( n = 22), these analyses did not reach statistical significance ( Figure S9 ).

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Quantitative analysis by single-cell image cytometry showed a trend toward increased infiltration of Foxp3 + cells in the NR group; however, no significant differences were observed between the R and NR groups in the mean percentages of tumor-infiltrating CD4 + , CD8 + , Foxp3 + , PD-L1 + , or PD-L2 + cells ( p = 0.613, 0.694, 0.094, 1.000, and 0.867, respectively) ( Figures 1 E and S1 B).

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