Identification and multi-layered validation of seven diagnostic biomarkers for dilated cardiomyopathy via integrative machine learning, single-cell transcriptomics, and Mendelian randomization.

Front Cell Dev Biol · 2026 · PMC13286953 · PMID 42343898

Europe PMC DOI

hedged sentences

0.0630

closest p · 1.3× alpha

0.0630

boldest claim

The sentences

did not reach statistical significanceP = 0.063so close (0.05 < p ≤ 0.1)

CSDC2 showed a nominal association with cardiomyopathy that did not reach statistical significance (OR = 1.321, 95% CI: 0.985–1.771, P = 0.063), while HMOX2 showed a non-significant protective direction (OR = 0.874, 95% CI: 0.702–1.088, P = 0.229) ( Figure 8A ).

also in 111,027 other papers

nominally significantno p-value reported

3.8.2 Reverse MR (heart failure → gene expression) AQP3 was the only candidate with a nominally significant reverse-direction signal.

also in 7,732 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.