Neoadjuvant camrelizumab plus chemotherapy in resectable stage IIIA-IIIB non-small cell lung cancer: integrated multidimensional biomarker analysis from a phase II study.

Stratification based on CD8+ naïve-like T-cell infiltration revealed that patients with high baseline levels in the TME or tumor nests experienced no disease progression during follow-up, although the associations with DFS did not reach statistical significance (TME: p=0.119; tumor nests: p=0.233) ( figure 4g,h ).

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However, post-NAT assessments showed a decreasing trend in ctDNA levels in the pCR group versus the non-pCR group (p=0.264), as well as in the MPR group versus the non-MPR group (p=0.170) ( figure 2b,c ).

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Conversely, higher baseline levels of CD8+ naïve-like T cells in both peripheral blood and tumor nests were also observed in patients achieving pCR and showed a trend toward longer DFS.

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