Novel insights into gut microbiota alterations in major depressive disorder with suicidal ideation: a metagenomic analysis.

Although many individual KOs did not reach the stringent significance threshold, several key genes involved in peptidoglycan metabolism, such as K00687 and K12556, showed a strong trend toward enrichment in the NSI group (with q -values approaching 0.1).

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Notably, while this species did not reach statistical significance under the stringent q < 0.1 threshold in the fully adjusted MaAsLin2 model, the model analysis results showed a degree of consistency with the visualized gradient, as the abundance trend remained stably declining in SI.

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