CTSL loss leads to anti-PD-1 immunotherapy resistance in lung cancer by suppressing the anti-tumor function of peripheral CD8<sup>+</sup> T cells.

Front Immunol · 2026 · PMC13290973 · PMID 42358957

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did not reach statistical significanceno p-value reported

showed a trendno p-value reported

The suppression of IFN-γ also showed a trend toward reversal, although it did not reach statistical significance.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.

CTSL loss leads to anti-PD-1 immunotherapy resistance in lung cancer by suppressing the anti-tumor function of peripheral CD8&lt;sup&gt;+&lt;/sup&gt; T cells.

The sentences

CTSL loss leads to anti-PD-1 immunotherapy resistance in lung cancer by suppressing the anti-tumor function of peripheral CD8<sup>+</sup> T cells.