Grape Seed Proanthocyanidins Enhance Time-Dependent HO-1 Activation and Improve Redox Homeostasis in Obesity-Induced Hepatic Dysfunction.

Antioxidants (Basel) · 2026 · PMC13295885 · PMID 42352040

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did not reach statistical significanceno p-value reported

However, these variations remained modest and did not reach statistical significance at any specific Zeitgeber time (ZT).

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a clear trendno p-value reported

This hypothesis is strongly supported by our target analysis of the hepatic nuclear fraction at ZT13, which revealed a clear trend toward blunted NRF2 nuclear accumulation under obesogenic conditions.

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