Multimodal Proteomics Reveals Dysregulated Secretion and ECM Remodelling in Schizophrenia Patient iPSC-Derived Astrocytes.

Although we detected EV marker proteins (e.g., CD63 and CD81), we did not observe a clear trend in regulation for EV marker proteins in lysates and ACM, suggesting that the quantity of EVs was not altered in the SCZ context.

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Interestingly, a marker of autophagic EVs, Sequestosome-1 (SQSTM1), was down-regulated at a near-significant level (q-value: 0.017) in the SCZ cell lysates ( Figure S3e ).

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