Clinical and Pathological Features That Predict High-Grade B-Cell Lymphomas (HGBCLs) with MYC and BCL2 or BCL6 Translocations (Double-Hit Lymphoma): A Systematic Review and Meta-Analysis.

Biomedicines · 2026 · PMC13297255 · PMID 42351803

Europe PMC DOI

hedged sentences

0.0510

closest p · 1.0× alpha

0.0510

boldest claim

The sentences

a near-significant trendp = 0.051so close (0.05 < p ≤ 0.1)

We identified a near-significant trend for c-Myc protein positivity in DHL (RR 1.41, p = 0.051), which has previously been reported to predict MYC rearrangement with variable accuracies [ 71 , 72 ].

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did not reach statistical significanceno p-value reported

Histopathological Features c-Myc protein expression was more likely in DHL than non-DHL patients (RR 1.41, p = 0.051) and approached but did not reach statistical significance.

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just failed to reach statistical significanceno p-value reported

Individual features that may warrant further investigation include c-Myc immunostaining, which just failed to reach statistical significance.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.

Clinical and Pathological Features That Predict High-Grade B-Cell Lymphomas (HGBCLs) with &lt;i&gt;MYC&lt;/i&gt; and &lt;i&gt;BCL2&lt;/i&gt; or &lt;i&gt;BCL6&lt;/i&gt; Translocations (Double-Hit Lymphoma): A Systematic Review and Meta-Analysis.

The sentences

Clinical and Pathological Features That Predict High-Grade B-Cell Lymphomas (HGBCLs) with <i>MYC</i> and <i>BCL2</i> or <i>BCL6</i> Translocations (Double-Hit Lymphoma): A Systematic Review and Meta-Analysis.