Real-World Outcomes of Nivolumab Plus Ipilimumab in Metastatic Melanoma: A Stratified Analysis of First- and Second-Line Treatment

Cancers (Basel) · 2026 · PMC13297584

Europe PMC

hedged sentences

0.0830

closest p · 1.7× alpha

0.0830

boldest claim

The sentences

showed a trendp = 0.083so close (0.05 < p ≤ 0.1)

In our cohort, female sex showed a trend toward association with worse OS (HR 1.49; 95% CI, 0.95–2.35; p = 0.083), although this did not reach statistical significance.

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did not reach statistical significanceno p-value reported

Female sex (HR 1.49; 95% CI, 0.95–2.35) and the occurrence of irAEs (HR 0.66; 95% CI, 0.42–1.04) showed trends toward association with OS but did not reach statistical significance. 3.5.

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