Tissue penetration of anti-tumour necrosis factor therapy in perianal fistulising Crohn's disease: a proof-of-concept study.

Eur J Gastroenterol Hepatol · 2026 · PMC13299039 · PMID 41784425

Europe PMC DOI

hedged sentences

0.0800

closest p · 1.6× alpha

0.0800

boldest claim

The sentences

showed a trendP = 0.08so close (0.05 < p ≤ 0.1)

Higher fistula-to-serum ratios showed a trend towards improved downstaging of the disease according to the TOpClass classification ( P = 0.08) and radiological improvement ( P = 0.16) at 2 years (Fig. 3 ).

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did not reach statistical significanceno p-value reported

Better tissue penetration was associated with a trend towards more favourable treatment outcomes; however, these did not reach statistical significance, likely due to the small sample size.

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