Functional Iron-Transport Genes—TF and TMPRSS6—As Genetic Determinants of Transferrin and Fasting Glucose in a Kazakh Adult Cohort: A Whole-Exome Sequencing Pilot Study

Int J Mol Sci · 2026 · PMC13299320

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hedged sentences

0.0980

closest p · 2.0× alpha

0.0980

boldest claim

The sentences

showed a trendp = 0.098so close (0.05 < p ≤ 0.1)

Transferrin saturation (TSAT) showed a trend toward lower values in MetS (21.0 vs. 26.5%; p = 0.098).

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did not reach statistical significanceno p-value reported

Among women (n = 62), the TMPRSS6 C–G–C haplotype was significantly associated with lower glucose levels (β = −0.79; p = 0.048), whereas in men (n = 34) the effect size was substantially larger (β ranging from −2.10 to −2.80) but did not reach statistical significance due to the limited sample size ( Figure 5 ). 2.6.

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