Lactate-Mediated Brain Acidosis Drives Epigenetic Dysregulation of TGFB2 and Associated Gene Networks in Schizophrenia and Bipolar Disorder

Int J Mol Sci · 2026 · PMC13299459

Europe PMC

hedged sentences

0.0700

closest p · 1.4× alpha

0.1500

boldest claim

The sentences

a positive trendp = 0.07so close (0.05 < p ≤ 0.1)

Notably, CA2 expression was not significantly altered in postmortem brain samples from SCZ or BD patients, and antipsychotic drug use showed an inverse trend with CA2 expression in SCZ (r = −0.59, p = 0.07) and a positive trend in BD (r = 0.60, p = 0.07).

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showed a trendp = 0.15not close (p > 0.1)

SLC16A3 also showed a trend toward an inverse correlation with brain pH in controls (r = −0.49, p = 0.15) and a significant inverse correlation in SCZ (r = −0.65, p = 0.04), but not in BD (r = +0.49, p = 0.15).

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did not reach statistical significanceno p-value reported

Postmortem interval (PMI) was also approximately 2 h longer in SCZ compared with controls; however, this difference did not reach statistical significance.

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