Aortic Single-Cell Transcriptome Analysis Reveals ApoE-Isoform-Specific Influences on Vascular Disease

Human apoE Polymorphism Differentially Impacts Western Diet-Induced Atherosclerosis in Mice Previous studies have reported that, in comparison to APOE3 mice, APOE2 mice displayed increased atherosclerosis and xanthomas while APOE4 mice also showed a trend toward more atherosclerosis when these animals were fed an atherogenic diet containing very high cholesterol content and sodium cholate [ 30 , 31 ].

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When the animals were sacrificed after 16 weeks on a Western diet, en face analysis of the whole aorta revealed a trend toward increased atherosclerosis lesion area in APOE2 mice compared to APOE3 and APOE4 mice, but the difference did not reach statistical significance ( Figure 1 B).

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