Knockout of α-Synuclein Is Associated with Depression-like Behaviors by Altered Excitability of Medial Prefrontal Cortex Neurons in Mice

During the initial highly active phases, where animals inherently exhibit vigorous escape-oriented struggling, the reduction in immobility in the hM4Di + C21 group showed a clear trend but did not reach statistical significance ( Figure 5 F,G; Block 1: p = 0.1742; Block 2: p = 0.0672).

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