Curcumin and Its Derivatives as Anticancer Agents in Head and Neck Cancer: Molecular Mechanisms and Preclinical Evidence

Int J Mol Sci · 2026 · PMC13300372

Europe PMC

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did not reach statistical significanceno p-value reported

Although these improvements did not reach statistical significance, this may have been attributable to the limited sample size of the study [ 309 ].

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showed a trendno p-value reported

Thus, in patients with locally advanced or metastatic HNSCC, curcumin was evaluated for the treatment of cancer anorexia–cachexia, and it significantly improved muscle mass and showed a trend toward preservation of body fat mass and basal metabolic rate.

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